Circulating Osteoprotegerin and Receptor Activator for Nuclear Factor κB Ligand: Clinical Utility in Metabolic Bone Disease Assessment
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منابع مشابه
REVIEW: Circulating Osteoprotegerin and Receptor Activator for Nuclear Factor B Ligand: Clinical Utility in Metabolic Bone Disease Assessment
Context: The discovery of the receptor activator for nuclear factor B (RANK) ligand (RANKL)/RANK signaling pathway has marked a major advance in our understanding of the mechanisms controlling osteoclastogenesis. RANKL, expressed by preosteoblasts and stromal cells, binds to RANK, expressed by cells of the osteoclast lineage, inducing a signaling cascade leading to the differentiation and fusio...
متن کاملReceptor activator of nuclear factor-κB ligand and osteoprotegerin: maintaining the balance to prevent bone loss
Bone remodeling requires a precise balance between resorption and formation. It is a complex process that involves numerous factors: hormones, growth factors, vitamins, and cytokines, and notably osteoprotegerin (OPG) and receptor activator for nuclear factor-κB (RANK) ligand. The signaling pathway OPG/RANK/RANKL is key to regulation for maintaining the balance between the activity of osteoblas...
متن کاملCombined Hydroxyapatite Scaffold and Stem Cell from Human Exfoliated Deciduous Teeth Modulating Alveolar Bone Regeneration via Regulating Receptor Activator of Nuclear Factor-Κb and Osteoprotegerin System
Background: Tissue engineering using Stem cell from Human Exfoliated Deciduous Teeth (SHED) and a natural biomaterials biomaterial scaffold has become a promising therapy for the alveolar bone defect. The aim of this study was to analyze the Osteoprotegerin (OPG) and Receptor Activator of NF-Κb ligand (RANKL) expression after the application of Hydroxyapatite scaffold and SHED.Methods: A labora...
متن کاملReceptor Activator of Nuclear Factor Kappa B Ligand (RANKL) Levels in Peri-Implant Crevicular Fluid
Background: Receptor activator of nuclear factor kappa B ligand (RANKL) is one of the key cytokines in the induction of osteoclastogenesis both in vitro and in vivo.Several reports indicated the presence of sRANKL in gingival crevicular fluid of patients with periodontal diseases. Objective: To determine the presence of RANKL in peri-implant crevicular fluid samples of implants with peri-implan...
متن کاملosteoprotegerin and soluble receptor activator of nuclear factor-kappa b ligand in exudative age-related macular degeneration.
calcification and inflammation are among the important cases of exudative age-related macular degeneration (e-armd). the aim of the present study was to elucidate if there is any relationship between serum osteoprotegerin (opg), soluble receptor activator of nuclear factor-kappa b ligand (rank-ligand) and e-armd. in a cross-sectional study, we compared 45 e-armd patients with 45 matched control...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2005
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jc.2005-0794